Resources with keywords: post-exposure prophylaxis
On September 10, 2026, the CDC issued CDCHAN-00533 warning of rising human rabies exposures and post-exposure prophylaxis (PEP) delivery errors. Inquiries rose 17%, with a 76% surge in rabies immune globulin (HRIG) use. Key clinical errors include gluteal vaccination, failing to infiltrate wounds with HRIG, and co-administering HRIG and vaccine in the same syringe. Routine diagnostic work on animal neural tissues or patient specimens requires BSL-2 containment by pre-vaccinated personnel. High-concentration viral propagation strictly requires BSL-3 facilities.
Autochthonous clade Ib transmission confirmed in EU/EEA. Outside Africa, 97% of cases are male, 89% MSM — pattern relevant to clinical triage and ED screening protocols. Laboratory personnel should note that standard dermatopathology laboratory procedures (formalin fixation) adequately inactivate orthopoxviruses; however, unfixed specimens require BSL-2 handling. ECDC recommends JYNNEOS post-exposure prophylaxis for HCWs with unprotected exposure within 4 days.
