Anthology of Biosafety

Anthology of Biosafety I: Perspectives on Laboratory Design

Contents: Management of Biosafety – Design Issues at the Management/Facility Interface – Primary Biocontainment Devices – HVAC Issues in Secondary Biocontainment – Open BSL-2 Laboratories – Facility Guidelines for BSL-2 and BSL-3 Biological Laboratories – Design of BSL-3 Laboratories – Building a Maximum Containment Laboratory – Designing the BSL-4 Laboratory – Role of the Class III Cabinet in Achieving BSL-4 – Containment Design Concepts for Extraterrestrial Sample Return – Biosafety Considerations for Design of Large-Scale Facilities – Small Animal Research Facilities and Equipment – Small Animal Research Facility Management – Large Animal Research Facilities – Waste Management Considerations

Anthology of Biosafety II: Facility Design Considerations

Contents: Working Safely with Wild Poliovirus – Biocontainment of Highly Pathogenic Avian Influenza Viruses – Maximum Containment for Researchers Exposed to Biosafety Level 4 Agents – Modular/Mobile BSL-2/3 Laboratories – Facility Maintenance Operations (Skilled Trades) for Biological Containment Laboratories – Construction and Commissioning Guidelines for Biosafety Level 4 (BSL-4) Facilities – Safety and Health Considerations for Conducting Work with Biological Toxins – Primary Containment Devices for Toxicological Research and Chemical Process Laboratories – Toxicology Laboratories – Medical and Infectious Waste Management

Anthology of Biosafety III: Application of Principles

Contents: Risk Assessment for Working with Infectious Agents in the Biological Laboratory – Biosafety Considerations in rDNA: Viral Gene Transfer Vectors, DNA-based Vaccines and Xenotransplantation – Biological Safety and the Academic Environment – Biosafety Issues in Hospital Settings – An Overview: Biological Safety from a Global Perspective – Beyond Compliance: Global Biological Safety at Johnson & Johnson – Twenty Years of Global Biosafety Programs – Ergonomic Considerations in Biomedical Research Laboratories

Anthology of Biosafety IV: Issues in Public Health

Contents: Autopsy Biosafety – Emerging Infectious Diseases – Emergency Response Action Plan for Pathogens – Bioterrorism: Public Health Preparedness – Biological/Chemical Terrorism and the University – Establishing a European Network for the Diagnosis of “Imported” Viral Diseases (ENIVD) – Global Perspectives on Infectious Substance Transportation – Biosafety Needs in Laboratories in Developing Countries – Biosafety in Brazil: Past, Present, and Prospects for the Future – Understanding, Assessing, and Communicating Topics Related to Risk in Biomedical Research Facilities – Status of Schools of Public Health in Educating Public Health Laboratory Scientists – The Public Health Laboratory System—Is It Prepared? – Managing and Using Immunization and Medical Surveillance Data – Biosafety in Public Health Laboratories – Biological Safety and Public Health Laboratory Design – Design Issues for Insectaries – Bioterrorist Threats to the Food Supply – Emerging and Reemerging Bacterial Zoonotic Infections in Russia: Current Trends – Investigations of Emerging Zoonotic Diseases – Agricultural Pathogens, Biological Containment, and the Biological and Toxin Weapons Convention

Anthology of Biosafety V: BSL-4 Laboratories

Contents: The Evolution of Biosafety from the U.S. Biological Warfare Program (1941-1972) – Anthology of Some Biosafety Aspects in Russia (up to 1960) – Emerging and Reemerging Infectious Diseases: A Global Perspective – Emergence of Bacterial and Other Zoonoses: Why Always A Surprise? – Why Does Brazil Need a Biosafety Level 4 Facility? – Security Considerations for Microbiological and Biomedical Facilities – Polio Virus Laboratories – The Polio Facility at SSI in Denmark: GMP and Containment – A Comparison of Containment Facilities and Guidelines in Russia and the United States – Working at Biocontainment Level 4—Contain the Operator or Contain the Bug? – A Class III Cabinet BSL-4 Laboratory – BSL-4 Laboratory Guidelines – Class III Cabinet Line in Japan – Validation of a BSL-4 Laboratory – Medical Emergency Planning for BSL-4 Containment Facilities – Monitoring of Specific Contamination of Virology Laboratories During Work with Filoviruses – Performance Verification of Containment Level 4 Laboratories: The Canadian Approach – Design and Operation of a High-Containment Sewage Treatment Facility – Animal Experimentation in Level 4 Facilities – Animal Necropsy in Maximum Containment

Anthology of Biosafety VI: Arthropod Borne Diseases

Contents: Arthropod Vectors and Their Role in Transmitting Pathogens to Humans and Animals – Laboratory-acquired Infections – Biosafety Issues and Solutions for Working with Infected Mosquitoes – Working Safely with Recombinant Viruses and Vectors – Protect Yourself and Your Sample: Processing Arbovirus-infected Biting Midges for Viral Detection Assays and Differential Expression Studies – Isolation of Arboviruses from Field-collected Mosquitoes – Arthropod Containment Guidelines – Safe and Secure Handling of Virus-exposed Biting Midges Within a BSL-3-Ag Containment Facility – An Alkaline Hydrolysis Tissue Digestion System for a BSL-3-Ag Containment Facility – Organizing and Carrying Out Work with Animals Under Stationary Laboratory and Field Conditions – Biosafety Practices in Field Research: A Reviewed Experience – Collaborative Research on Crimean-Congo hemorrhagic fever virus at SRCVB “Vector”—Scientific and Biosafety Aspects

Anthology of Biosafety VII: Biosafety Level 3

Contents: Biosafety Level 3 Laboratory Design – Modular/Mobile BSL-2/3+ Laboratories – BSL-3 Insectary Facilities – From Dioxin to Anthrax: A Laboratory Redesign – Formaldehyde Fumigation for BSL-3 Facilities – The Class III Biological Safety Cabinet – Comparative Pathology in Biosafety Level 3 Containment – Biocontainment in Developing Countries – Biosafety, Field Research, and Issues Related to Emerging Diseases in Brazil – Some Biosafety Considerations for Special Agents Using BSL-3 Facilities in Brazil – Procedures for Wild Poliovirus Containment at the Time of Global Certification of Polio Eradication – The Moment of Truth: Crisis Communication for Laboratories – Transport of Infectious Substances—The Development of New Regulations – Community Relations for High-Containment Laboratories: The Canadian Science Centre for Human and Animal Health Model – Treatment of Solid and Liquid Biowaste and ISO Registration of the Process – U.S. Laboratory Response Network and Its International Expansion

Anthology of Biosafety VIII: Evolving Issues in Containment

Contents: Toward Global Biosafety Harmonization – Emerging Challenges to Containment: Development of a Biodefense Infrastructure – Brazilian Experience in Implementation of Biosafety Level 3 Laboratories (BSL-3) – Design Considerations for Large-Scale Production of Biologicals: GMP and Containment Synergies – Animal Room Design Issues in High-Containment – Mobile/Modular Containment Facilities – Management of Multihazardous Wastes from High-Containment Laboratories – Viral Genetic Diversity Network (VGDN) in Brazil – Working Safely with the Transmissible Spongiform Encephalopathies

Anthology of Biosafety IX: Exploring the Performance Envelope for BSL-3 and BSL-4 Laboratories

Contents: Emerging Infections and Healthcare Settings – Biosafety: Emerging Issues and International Challenges – The BSL-4 Laboratory: Perspective Verses Reality – Design and Ongoing Operational Challenges for Building Automation Systems in a Containment Facility – Steam Effluent Decontamination System – Design Guidelines for Public Health Laboratory Facilities in Brazil – Developing a Unit to Care for Patients with Highly Communicable, Serious Infectious Diseases – The Nebraska Biocontainment Patient Care Unit – Technological Integration and Development of the Modern Mobile Laboratory – Certification Process of a Biosafety Level-3 Facility in Nebraska’s State Public Health Laboratory – Operation of a High-Containment Laboratory Using Select Agents – Managing Animals in Containment—A Director’s View – Modern Biological Safety Standards in Tuberculosis Diagnostic (Clinical) Laboratories – Biosafety Enclosures for Automated Laboratory Equipment – Performing Small Particle Research in New Environments with Robotic Applications – Aerobiology Containment Systems – Decontamination and Disinfection Validation of Viral Agents in an Industrial Environment – Operating a BSL-3 Facility Under GMPs – Challenges of GMP Requirements in Containment Design: What do the Regulations Say?

Anthology of Biosafety X: Animal Biosafety

Contents: Expectations of the USDA Animal Care Inspector in Barrier Facilities – Aerosol Infection of Small Animals—Safety Considerations – Medical Surveillance for Personnel Working with Animals – Transport of Infectious Materials – Animal Biosafety Level 3: Facility Design Considerations – Road Map to a Successful Program: How to Put It All Together – Animal Biosafety Level Determinations – ABSL-3 Caging – Public Communication and BSL-4 Labs: The UC Davis Experience – Safety in the Biomedical Laboratory – Biocontainment Recommendations for Animal Agricultural Pathogens – A Class III Cabinet BSL-4 Laboratory – Using Viral Vectors in Animal Research – Advanced Technologies in Animal Research – Managing Students and Other Academic Challenges in Animal Biocontainment Facilities – Meeting the Challenges of High-Containment Animal Care – Medical Management of Exposures to Biological Threat Agents – Transport of Animals – Navigating Through IACUC—IACUC and IACUC-IBC Overlaps: Jointly Sponsored Research and Peer Review of Hazardous Agent Use in Animals – BMBL: The New Edition – International Agriculture BSL-3/4 Facilities – Nonhuman Primate Husbandry and Procedures for ABSL-3 and ABSL-4 – Contract Staffing in Animal Biocontainment Facilities – IACUC Issues in Biocontainment Research

Anthology of Biosafety XI: Worker Health and Safety Issues

Contents: S.A.F.E.R. Together—Building a Multidisciplinary Biosafety Network – Serum Banking in Biomedical Research – Medical Countermeasures against Agents of Bioterrorism – Health and Safety During Public Health Responses and International Travel – Occupational Health Issues for Animal Care Workers – Laboratory Animal Allergy – Respirator Fit Testing—Does It Really Protect Me? – Overview of the Biosafety Risk Assessment Process – Bacterial and Fungal Infections among Diagnostic Laboratory Workers: Evaluating the Risks – Achieving a “Biosafety Culture” in Biomedical Laboratories – Biocontainment Training: Setting Minimal Training Standards for Personnel – Creating a Value-added Safety Culture – Biosafety in Research and Clinical Settings – Trends in Clinical Laboratory Design – Patient Facility Safety and Design – Biocontainment of Polio Vaccine Production and Laboratory Facilities – Core Issues in Retrofitting an Existing Facility – Communicating Effectively: The Key to Influencing Others

Anthology of Biosafety XII: Managing Challenges for Safe Operations of BSL-3/ABSL-3 Facilities

Contents: Strategies for Coping with Multiple Biological Safety Regulations in High- Containment Laboratories – Reports, Legislation, and the Policy Process: Biosecurity and the Select Agent Program – Biological Risk Assessment – Laboratory Emergencies and the Incident Command System: A Brief Introduction to Roles and Responsibilities – Laboratory Biosafety Competency Development for the BSL-2, -3, and -4 – Validation of Non-Traditional Containment Equipment – Joint Perspectives on Managing a High-Containment Facility: Principal Investigator and Biosafety Personnel – Training & Staff Management in the Midst of the 2009 A(H1N1) Influenza Virus Outbreak – Biosecurity Considerations for Containment Laboratories: Example of a Public University System – Laboratory Exposures to Botulinum Toxin: Review and Updates of Therapeutics for the Occupational Health Provider – An Innovative Approach to Controlling Waste Water in a Bio-Containment Laboratory – Energy Efficiency Considerations in BSL-3 and ABSL-3 Laboratories – Greening Biosafety Laboratories – Biocontainment Considerations for Agricultural Animal Species – Partnering with Communities for Biosafety’s Sake – Disaster Planning for Animal Biocontainment Facilities

The Anthology XII book has been reviewed by Veterinary Information Network, Inc. on the Veterinary Support Personnel Network website. VSPN and VIN Book Reviews are written by colleagues in veterinary medicine for our colleagues in veterinary medicine and all levels veterinary education. Some texts are available for purchase through the VIN store others will include the ISBN information on the book review.

Anthology of Biosafety XIII: Animal Production and Protection – Challenges, Risks, and Best Practices

Contents: Remarks by Under Secretary for Research, Education and Economics (REE) at the USDA ARS 1st International Biosafety and Biocontainment Symposium – Introduction to Biocontainment and Biosafety Concepts as They Relate to Research with Large Livestock and Wildlife Species – Defining Animal Biosafety Level 3 and 3 Ag – From the Field to the Laboratory in an Animal Disease Outbreak Situation – Working with Biosafety 3 Agents That Interface Across Human, Livestock, and Wildlife Boundaries – Controlling Laboratory Risk…in a Global Biotech Revolution – Commissioning the Biocontainment Lab: Paving the Way for Effective and Troublefree Operations – Liquid Effluent Decontamination Design and Operations – Carcass Disposal for Biocontainment Facilities – Working Safely with Rift Valley Fever Virus – The Anatomy of a Biosafety Audit Process: A Continuous Monitoring Model – Strategies for Communicating with the General Public About High-Containment Laboratories – International Challenges Related to Arthropod Containment – One Health: A Concept for the 21st Century

Anthology of Biosafety XIV: Sustainability

Contents: Thoughts on the Sustainability Challenge – Sustaining a Culture of Biosafety – The Basic Principles of Threat Assessment – Small, Medium, Large, Extra Large: Sustainable Biosafety & Biosecurity Solutions – Do Less, With Less. Get More: Navigating the Regulatory Landscape + Addressing Risk “Glocally” – A Sustainable BSL-3 Laboratory in a Platinum Leed® Building for Work with Tier 1 Select Agents – Healthier and More Engaged—Strategies for Sustaining a Thriving Workforce – Sustainability Is a Team Sport—Improving Worker Health Through Biosafety and Sustainability – Reducing Laboratory Energy Use with Demand-based Control – Biological Safety Cabinet Energy and Safety Considerations – Class II Biosafety Cabinet Sustainability – Green Autoclaves (Steam Sterilizers) – First Steps in Establishing Sustainability in an Animal Containment Environment – Safety, Sustainability, and Common Sense in the Vivarium: Mutually Exclusive Goals? – Sustainable Animal Facilities—Design and Operational Considerations – Challenges to Sustainability of Biosafety and Biosecurity Programs in Uganda: Analysis of National Laboratory Assessment, USAID STAR-EC Laboratory Rapid Needs Assessment and Laboratory Audit Reports – Sustainable Biosafety Communities