Prion Diseases Toolbox for biosafety/biosecurity professionals: current and relevant resources compiled from organizations, government agencies, and news outlets.
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Milstein M, Gresch SC, Schwabenlander MD, Li M, Bartz JC, Bryant DN, et al.
Steel and plastic surfaces used in venison processing can be directly contaminated with CWD prions, contributing to cross-contamination of CWD-negative venison. Several decontaminant solutions (commercial bleach and potassium peroxymonosulfate) are efficacious for prion inactivation on these surfaces.
Lab testing, case definition
Infection control measures and example of patient management ( appropriate confinement, containment, safe handling, disinfection, and disposal of contaminated materials and tissues generated during the course of hospitalization)
Infection control measures and Recommendations for disinfection and sterilization of prion-contaminated medical devices
Mead, Simon et al.
The Lancet Neurology, Volume 20, Issue 12, 981
The UK’s Advisory Committee for Dangerous Pathogens convened a subgroup to revise guidance for safe working with prions and to consider whether any measures were needed for work with proteopathic seeds, involving experts from research laboratories for prion and other neurodegenerative diseases, infectious disease specialists, pathologists, veterinarians, and health and safety experts.
Flow chart to manage samples from human or animal source
This guidance produced by the ACDP TSE risk management subgroup aims to help minimise the risk of transmission of Creutzfeldt-Jakob disease (CJD) and variant Creutzfeldt-Jakob disease (vCJD) in healthcare and other work settings.
The following management plan will guide Texas Parks and Wildlife Department (TPWD) and Texas Animal Health Commission (TAHC) in addressing risks, developing management strategies, and protecting big game resources from chronic wasting disease (CWD) in captive and free-ranging cervid populations in the state of Texas.
Flow chart to manage samples from human or animal source
The National Prion Disease Pathology Surveillance Center (NPDPSC) is the only Center of its kind in the U.S. We coordinate autopsies and neuropathologic examinations of suspected prion disease cases from across the country. Local autopsies are performed on-site, and other cases are performed elsewhere through a network of providers that the Center coordinates.
The CWD set of pages is a special project under CIDRAP. It contains information about latest cases reported in the US and FAQs
Rutala W, et al.
The recommendations in this article consider inactivation data but also use epidemiological studies of prion transmission, infectivity of human tissues, and efficacy of removing microbes by cleaning.
Infection control measures and example of patient management ( appropriate confinement, containment, safe handling, disinfection, and disposal of contaminated materials and tissues generated during the course of hospitalization)
Infection control measures and Recommendations for disinfection and sterilization of prion-contaminated medical devices
Mead, Simon et al.
The Lancet Neurology, Volume 20, Issue 12, 981
The UK’s Advisory Committee for Dangerous Pathogens convened a subgroup to revise guidance for safe working with prions and to consider whether any measures were needed for work with proteopathic seeds, involving experts from research laboratories for prion and other neurodegenerative diseases, infectious disease specialists, pathologists, veterinarians, and health and safety experts.
This article reviews the infection control guidance relative to iatrogenic transmission of CJD.
The purpose of this international meeting was to review the latest available data on the epidemiology, antemortem and postmortem diagnosis, detection of the infectious agents, and distribution of infectivity in tissues or body fluids of relevant species with TSEs.
Bruna C, et al.
This review sought to provide an overview of proposed methods and protocols for processing surgical instruments contaminated with prions.
Belondrade M, et al.
A current limitation for validating decontamination/sterilization of surgical instruments is the lack of a rapid model permissive to human prions. The authors developed a prion detection assay based on protein misfolding cyclic amplification (PMCA) technology combined with stainless-steel wire surfaces as carriers of prions (Surf-PMCA).
McDonnell J, et al.
investigate the combination of cleaning, disinfection and/or sterilization on reducing the risk of surface prion contamination.
Hadar J, Tirosh T, et al.
Early reference to inactivation of prions
Ami Patel, PhD, RBP (ABSA), Emerging Infectious Diseases Committee (EIDC), ABSA International
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