Resources with keywords: B cell depletion

State health notices documented fatal tick-borne infections across the Northeast. Rhode Island confirmed a fatal neuroinvasive Powassan virus case, marking the state’s third case in 2026. Simultaneously, Stony Brook Medicine confirmed the emergence of Bourbon virus on Long Island, transmitted by expanding Lone Star ticks (Amblyomma americanum). Bourbon virus causes acute leukopenia, thrombocytopenia, and organ failure with no commercial diagnostic assays. Laboratories performing tick identification or clinical blood analysis must operate under BSL-2 containment inside Class II Biosafety Cabinets, with tick dissection restricted to secondary containment.