Resources with keywords: VHF
Yang W, et al.
Highlights
- Recombinant vesicular stomatitis virus expressing Ebola virus glycoprotein is lethal in immunocompetent Syrian hamsters.
- The pathogenicity of VSV-EBOV/GP is species-specific, age-related, gender-associated, and challenge route-dependent.
- Syrian hamsters develop uveitis, multi-organ failure, and severe systemic diseases resembling symptoms of human EBOV patients.
- The model is available for anti-EBOV antibody and vaccine evaluation under BSL-2 conditions.
Coulborn R, et al
Vaccination with the Ebola vaccine significantly lowered case fatality risk vs not vaccinated.
Alert concerning two confirmed outbreaks of Marburg virus disease (MVD)—one in Equatorial Guinea and one in Tanzania.
This guidance applies to viral hemorrhagic fevers caused by infections with:
- Filoviruses (ebolaviruses and marburgviruses),
- Arenaviruses [Lassa, Lujo, and South American hemorrhagic fever viruses (Guanarito virus, Sabia virus,
- Junin virus, Chapare virus, Machupo virus)],
- Rift Valley fever virus, and
- Crimean Congo hemorrhagic fever virus.
The CDC is reporting a recently confirmed outbreak of Ebola virus disease (EVD) in Uganda caused by Sudan virus (species Sudan ebolavirus) to summarize CDC’s recommendations for U.S. public health departments and clinicians, case identification and testing, and clinical laboratory biosafety considerations.
Current approved vaccines cannot control this outbreak because it’s being driven by a distant viral relative of Zaire ebolavirus, known as Sudan ebolavirus, which last caused an outbreak, also in Uganda, in 2012.
