Resources with keywords: surrogate models
Establishment and application of a surrogate model for human Ebola virus disease in BSL-2 laboratory
Virologica Sinica
29 March 2024
Yang W, et al.
Highlights
- Recombinant vesicular stomatitis virus expressing Ebola virus glycoprotein is lethal in immunocompetent Syrian hamsters.
- The pathogenicity of VSV-EBOV/GP is species-specific, age-related, gender-associated, and challenge route-dependent.
- Syrian hamsters develop uveitis, multi-organ failure, and severe systemic diseases resembling symptoms of human EBOV patients.
- The model is available for anti-EBOV antibody and vaccine evaluation under BSL-2 conditions.
