Resources with keywords: H5N1 D1.1
Replication Efficiency of Contemporary Highly Pathogenic Avian Influenza A(H5N1) Virus Isolates in Human Nasal Epithelium Model
CDC / Emerging Infectious Diseases
5 May 2026
Genotype D1.1 H5N1 viruses replicate significantly more efficiently in human nasal epithelium organoids than genotype B3.13. This finding has direct biosafety implications for laboratory workers: D1.1 strains pose greater occupational infection risk and may require enhanced containment measures beyond current BSL-3 enhanced (Ag) standards. Dual-use research of concern (DURC) policies apply. Biosafety officers at labs conducting avian influenza research should review containment adequacy for D1.1 strains.
