Professional “burnout” arises from constant exposure to emotional and interpersonal stress and has been defined by the psychological community as exhibiting dimensions of exhaustion, cynicism, and inefficacy. While traditional means of addressing burnout include interventions such as rest, proper diet, and techniques for relaxation, an emerging body of knowledge is also identifying positive engagement as a promising option for consideration. The dimensions of engagement include renewed dedication, absorption, and vigor. In other words, reframing the way individuals approach their work and establishing strategies for gaining control of their careers can be a powerful means of addressing burnout. In this presentation, four practicing and credentialed biosafety professionals will share their collective experiences on how enhanced control over and a better understanding of the role of biosafety’s role can lead to a more professionally rewarding career. Strategies and examples of the techniques that have been used to achieve these goals will be described, and ample time will be allocated for questions and discussion.